Output ID:  1000022440112
Category:  期刊论文
Journal Article Title:  :  3D-Printed Poly(epsilon-caprolactone) Scaffold Augmented With Mesenchymal Stem Cells for Total Meniscal Substitution: A 12- and 24-Week Animal Study in a Rabbit Model.
Abstract:  BACKGROUND: Total meniscectomy leads to knee osteoarthritis in the long term. The poly(epsilon-caprolactone) (PCL) scaffold is a promising material for meniscal tissue regeneration, but cell-free scaffolds result in relatively poor tissue regeneration and lead to joint degeneration. HYPOTHESIS: A novel, 3-dimensional (3D)-printed PCL scaffold augmented with mesenchymal stem cells (MSCs) would offer benefits in meniscal regeneration and cartilage protection. STUDY DESIGN: Controlled laboratory study. METHODS: PCL meniscal scaffolds were 3D printed and seeded with bone marrow-derived MSCs. Seventy-two New Zealand White rabbits were included and were divided into 4 groups: cell-seeded scaffold, cell-free scaffold, sham operation, and total meniscectomy alone. The regeneration of the implanted tissue and the degeneration of articular cartilage were assessed by gross and microscopic (histological and scanning electron microscope...
Keywords:  knee; meniscus; stem cell therapy; tissue engineering 
Authors:  Zhang, Zheng-Zheng; Wang, Shao-Jie; Zhang, Ji-Ying; Jiang, Wen-Bo; Huang, Ai-Bing; Qi, Yan-Song; Ding, Jian-Xun; Chen, Xue-Si; Jiang, Dong; Yu, Jia-Kuo
Journal Name:  The American Journal of Sports Medicine 
Status:  Published
Publication Date/Period:  2017-6 
Issue No.: 
Volume No.:  45 
Pages:  1497-1511 
Indexed by:  other
DOI:  10.1177/0363546517691513
Times Cited:  37
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Last update date:  2020/03/11 18:22:25