|Journal Article Title: :
||Recent progress on the discovery of NLRP3 inhibitors and their therapeutic potential
<jats:p> Inflammation is the fast coordinating response of body’s immune system to irritants caused by pathogens, external injuries and chemical or radiation effects. The NLRP3 (nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3) inflammasome is a critical component of the innate immune system. Malfunction of NLRP3 inflammasome will contribute to various pathogenesis of complex diseases, such as uncontrolled infection, autoimmune diseases, neurodegenerative diseases, and metabolic disorders. This review aims to describe recent progress on discovery of NLRP3 inflammasome inhibitors and their therapeutic potential.
<jats:p> Based on the mechanism of NLRP3 activation, several types of NLRP3 inhibitors were described and summarized according to their origins, structures...
||Ma, Su; Weiwei, Wang; Feng, Liu; Huanqiu, Li
||Current Medicinal Chemistry
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