Output ID:  1000022440115
Category:  期刊论文
Journal Article Title:  :  Role of scaffold mean pore size in meniscus regeneration.
Abstract:  UNLABELLED: Recently, meniscus tissue engineering offers a promising management for meniscus regeneration. Although rarely reported, the microarchitectures of scaffolds can deeply influence the behaviors of endogenous or exogenous stem/progenitor cells and subsequent tissue formation in meniscus tissue engineering. Herein, a series of three-dimensional (3D) poly(epsilon-caprolactone) (PCL) scaffolds with three distinct mean pore sizes (i.e., 215, 320, and 515mum) were fabricated via fused deposition modeling. The scaffold with the mean pore size of 215mum significantly improved both the proliferation and extracellular matrix (ECM) production/deposition of mesenchymal stem cells compared to all other groups in vitro. Moreover, scaffolds with mean pore size of 215mum exhibited the greatest tensile and compressive moduli in all the acellular and cellular studies. In addition, the relatively better results of fibrocartilaginous...
Keywords:  *Meniscus tissue engineering; *Microstructure; *Polymer; *Porous scaffold; *Structure-property relationship 
Authors:  Zhang, Zheng-Zheng; Jiang, Dong; Ding, Jian-Xun*; Wang, Shao-Jie; Zhang, Lei; Zhang, Ji-Ying; Qi, Yan-Song; Chen, Xue-Si; Yu, Jia-Kuo*
Journal Name:  Acta Biomaterialia 
Status:  Published
Publication Date/Period:  2016-10-1 
Volume No.:  43 
Pages:  314-326 
Indexed by:  other
DOI:  10.1016/j.actbio.2016.07.050
Times Cited:  40
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Last update date:  2020/03/06 18:10:05 
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