A New, Simple, One-Pot Route for the Synthesis of Triazepin-8-one Derivatives

作者：Zeng, Hui; Zhang, Xiao; Deng, Yayun; Chang, Yaning; Shao, Xusheng; Xu, Xiaoyong; Li, Zhong^*

来源：Synlett, 2016, 27(3): 442-446.

DOI：10.1055/s-0035-1560499

• imidazol-6-ones
• one-pot
• triazepin-8-one
• ring-opening
• cyclization

A novel procedure for constructing triazepin-8-one skeletons under mild conditions in one pot was developed. The access to triazepin-8-ones was achieved via direct amination of imidazol-6-ones with aqueous ammonia and cyclization with formaldehyde. The experimental simplicity and moderate to good yields are the main features of this method.

• 出版日期2016-2
• 单位华东理工大学