A PIM2 analogue suppresses allergic airway disease

作者：Harper Jacquie L; Hayman Colin M; Larsen David S^*; Painter Gavin F; Singh Gill Gurmit

来源：Bioorganic & Medicinal Chemistry, 2011, 19(2): 917-925.

DOI：10.1016/j.bmc.2010.11.058

• Phosphatidylinositol mannans
• PIMs
• PIM analogues
• Asthma
• Inflammation

Two approaches for the synthesis of a phosphatidylinositol dimannoside (PIM2) analogue 4 that mimics the suppressive activity of natural PIMs and also synthetic PIM2 have been developed. This analogue, where the inositol core was replaced by glycerol, was tested for its ability to suppress cellular inflammation in a mouse model of allergic asthma and shown to be effective in suppressing airway eosinophilia. Suppression of all inflammatory cells monitored was observed, indicating a general blockade of cellular activity. These data indicate that the inositol core is not essential for this suppressive activity.

• 出版日期2011-1-15
• 单位河北医科大学