Antidepressant Effects of Ketamine on Depression-like Behavior in Juvenile Mice after Neonatal Dexamethasone Exposure

作者：Li Su Xia; Zhang Ji Chun; Wu Jin; Hashimoto Kenji^*

来源：Clinical Psychopharmacology and Neuroscience, 2014, 12(2): 124-127.

DOI：10.9758/cpn.2014.12.2.124

• Depression
• Dexamethasone
• Ketamine
• NMDA receptors
• Antidepressants

Objective: Pediatric depression is associated with significant functional impairment at school and at work, Recently, we reported on depression-like behavior in juvenile mice neonatally exposed to dexamethasone (DEX) as a potential animal model for pediatric depression, The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has promoted rapid and long lasting antidepressant effects in patients with treatment-resistant major depression. This study was conducted to examine whether ketamine had antidepressant effects in juvenile mice after neonatal DEX exposure, %26lt;br%26gt;Methods: A single dose (10 mg/kg) of ketamine or vehicle was injected into juvenile mice at days 29-32 after neonatal DEX (or saline) exposure (days 1-3). The sucrose preference test, tail suspension test, and forced swimming test were performed 24, 40, and 46 hours, respectively, after injection of ketamine. %26lt;br%26gt;Results: Ketamine (10 mg/kg) significantly improved depression like behavior in DEX treated juvenile mice, %26lt;br%26gt;Conclusion: This finding suggests that ketamine confers antidepressant effects in an animal model of pediatric depression,

• 出版日期2014-8
• 单位北京大学