MicroRNAs in modulating non-alcoholic steatohepatitis

作者：Shu, Xiangbing; Zhang, Li; Ji, Guang^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(3): 5366-5378.

• MicroRNAs
• non-alcoholic steatohepatitis
• liver
• inflammation
• regulation

Nonalcoholic fatty liver disease (NAFLD) has become a major worldwide health problem recently. The initial nonalcoholic fatty liver (NAFL) is usually considered to be benign, but it has the progressive potential, which can progress into nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. NASH is characterized by steatosis and inflammation, and is the indicator of liver injury. Though the exact mechanisms of NASH are still inclusive, studies implicated the inflammatory process may relate to a multiple disorders, such as abnormal lipid metabolism and secretion of adipokines, dysfunction of Kupffer cells (KCs), alteration of intestinal environment and autophagy response, et al. MicroRNAs (miRNAs), the small non-coding RNA molecules that mainly function in regulating RNA silencing and post-transcriptional of gene expression, are reported to be involved in the development of NASH in recently studies. In this review, we highlight miRNAs studies targeting NASH and related pathological processes, and try to analyze and discuss their therapeutic and predictive potentials on NASH patients.

• 出版日期2016
• 单位上海中医药大学