Aflatoxin and PAH exposure biomarkers in a U.S. population with a high incidence of hepatocellular carcinoma

作者：Johnson Natalie M; Qian Guoqing; Xu Li; Tietze Danielle; Marroquin Cardona Alicia; Robinson Abraham; Rodriguez Melanie; Kaufman Linda; Cunningham Kyle; Wittmer James; Guerra Fernando; Donnelly Kirby C; Williams Jonathan H; Wang Jia Sheng; Phillips Timothy D^*

来源：Science of the Total Environment, 2010, 408(23): 6027-6031.

DOI：10.1016/j.scitotenv.2010.09.005

• Aflatoxin
• Polycyclic aromatic hydrocarbons
• Hepatocellular carcinoma
• Hepatitis C virus
• Biomarkers of exposure
• Food safety
• Biomonitoring

The incidence of hepatocellular carcinoma (HCC) is significantly elevated in a Hispanic community in Bexar County. Texas Chronic exposure to dietary aflatoxins (AFs) is a major risk factor for HCC, increased risk has been linked to polycyclic aromatic hydrocarbon (PAH) co-exposure and hepatitis virus infection. The aims of this study were to assess AF and PAH exposures, investigate dietary factors that may contribute to Increased AF exposure, and determine the prevalence of hepatitis virus infection in Bexar Co Blood and urine samples were collected from 184 volunteers for biomarker analyses and hepatitis screening Serum AFB(1)-lysine adduct, urinary AFM(1) and 1-hydroxypyrene (1-OHP) levels were measured using high-performance liquid chromatography The average AFB(1)-lysine adduct level detected in 20.6% of serums was 3.84 +/- 3 11 pg/mg albumin (range 1 01-16 57 pg/mg) AFM(1) was detected in 11.7% of urines, averaging 223 85 +/- 250 56 pg/mg creatinine (range 1 89-935.49 pg/mg). AFM(1) detection was associated with increased consumption of corn tortillas (p = 0 009), nuts (p = 0 033) and rice (p = 0 037). A significant difference was observed between mean 1-OHP values of non-smokers (0.07 +/- 0 13) and smokers (0.80 +/- 0 68) mu mol/mol creatinine (p<0.01). A high hepatitis C virus positivity rate (7.1%) was observed Findings suggest that the incidence and level of AF and PAH exposure were less than those observed in a high-risk population; however, participants consuming higher amounts of foods prone to AF contamination may be more vulnerable to exposure and interactions with other environmental/biological factors (i.e.

• 出版日期2010-11-1