科研之友
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摘要
A practical synthesis of a novel class of fused heterocycles was developed from 1-(2-iodobenzyl)-1H-pyrrole and -indoles with various bromoalkyl aryl alkynes. This palladium(0)-catalyzed norbornene-mediated domino reaction allows the efficient formation of three carbon-carbon bonds in a one-pot procedure with PdCl(2) and tri-2-furylphosphine (TFP). in the presence of norbornene and Cs(2)CO(3) in acetonitrile at 90 degrees C. New seven-membered-ring fused heterocycles are obtained in moderate to excellent yields.
- 出版日期2009-4-1
