Analysis of changes in the immunological system during canine senescence and oncogenesis

作者：Kempisty Bartosz^*; Zawierucha Piotr; Zaorska Katarzyna; Dorszewska Jolanta; Bukowska Dorota; Jaskowski Jedrzej M; Nowicki Michal; Zabel Maciej

来源：Medycyna Weterynaryjna, 2011, 67(9): 594-598.

• senescence
• oncogenesis
• oxidative stress
• canine

Senescence of the organism is a consequence of several molecular (induction of proapoptotic genes expression, DNA damage) and biochemical changes, which gradually leads to the degeneration of some systems and organs. One of the most important features of progressive senescence is also a decreased response of the immunological system (proinflammatory response), which may result in a higher susceptibility to infection. The process of oncogenesis is closely associated with the age of an animal and progressive senescence. However, the proper assessment of the association between the induction of oncogenesis and senescence is problematic, mainly with regards to several species specific features like the weight of a dog or its breed. Moreover, the association between the activity of the immunological system and oncogenesis in a dog in an age-dependent manner is also unclear. Studies have suggested that the main factors which influence the process of senescence and oncogenesis are: DNA damage, spontaneous mutations, increase of oxidative stress and decrease of immunological system activity. in this article, the mechanisms and factors associated with oncogenesis and canine senescence have been presented. The authors have also described the role of selected proteins in the induction of these processes.

• 出版日期2011-9