Tumor Necrosis Factor Alpha Promoter Polymorphism in Posttransplantation Diabetes Mellitus of Renal Transplant Recipients

作者：Kao C C; Lian J D; Chou M C; Chang H R^*; Yang S F

来源：Transplantation Proceedings, 2010, 42(9): 3559-3561.

DOI：10.1016/j.transproceed.2010.06.032

Posttransplantation diabetes mellitus (PTDM) is a major complication in renal transplant recipients. Some studies have demonstrated that tumor necrosis factor alpha (TNF-alpha) expression and its genetic polymorphism are associated with diabetes mellitus. We investigated this association in Asian renal transplant recipients. Polymerase chain reaction-restriction-fragment length polymorphism was used to measure TNF-alpha G-238A and G-308A gene polymorphisms among 241 nonposttransplantation diabetic subjects and 73 PTDM patients. PTDM patients showed higher values of body weight and body mass index (BMI) than the non-PTDM group. However, no significant association was observed between TNF-alpha G-238A and TNF-alpha G-308A polymorphisms with PTDM incidence, gender, age at transplantation, follow-up duration, BMI, or type of immunosuppression.

• 出版日期2010-11
• 单位河北医科大学