A highly effective bifunctional ligand for radioimmunotherapy applications

作者：Chong Hyun Soon^*; Song Hyun A; Kang Chi Soo; Le Thien; Sun Xiang; Dadwal Mamta; Lee Hyunbeom; Lan Xiaoli; Chen Yunwei; Dai Anzhi

来源：Chemical Communications, 2011, 47(19): 5584-5586.

DOI：10.1039/c0cc05707j

A novel bifunctional ligand (3p-C-NETA) for antibody-targeted radioimmunotherapy (RIT) of beta-emitting radioisotopes (90)Y and (177)Lu was efficiently synthesized via an unexpected regiospecific ring opening of an aziridinium ion. 3p-C-NETA instantly formed a very stable complex with (90)Y or (177)Lu. 3p-C-NETA is an excellent bifunctional ligand for RIT.

• 出版日期2011