Autoimmune thyroid disease and PTPN22 gene polymorphisms of the correlation analysis

作者：Shen, Guo-Shuang; Zhao, Jiu-Da; Liu, Zhen; Cheng, Shan-Shan; Wu, Qiong^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(7): 14754-14757.

• Autoimmune thyroid disease
• PTPN22
• gene polymorphism
• relevance

Object: To analyze the relationship between PTPN22 gene polymorphism and autoimmune thyroid disease (AITD), and the relationship between SPTPN22 gene SNP and CTLA-4 gene SNP, in order to investigate the causes leading to AITD. Method: Selected 150 cases with Graves' disease (GD) from February 2014 to March 2015 in our hospital. 135 healthy people were taken as control. A single allele-specific primer - polymerase chain reaction technique (SASP-PCR) was to measure and analyze genotypes and alleles in GD and control groups. Result: In GD group and healthy control group, the distribution frequency of -1123 G>C was consistent with the Hardy-Weinberg genetic equilibrium law, as well as the distribution of CTLA-4 genotype. Comparing the genotype and allele distribution frequency of the two groups, the difference was statistically significant (P<0.05), as well as to CTLA-4. The rick of AITD with GG or AG genotype in CTLA-4 and CC genotype in PTPN22 was the 3.23 times of that with AA genotype in CTLA-4 and G genotype in PTPN22. Conclusion PTPN22 1123 G>C SNP genotypes might be related to the occurrence of AITD, and the C allele and the G of CTLA-4 gene could synergistically cause AITD.

• 出版日期2016
• 单位青海大学