Association between serum uric acid, high sensitive C-reactive protein and pro-oxidant-antioxidant balance in patients with metabolic syndrome

作者：Ahmadnezhad Mahsa; Arefhosseini Seyed Rafie; Parizadeh Mohammad Reza; Tavallaie Shima; Tayefi Maryam; Darroudi Susan; Ghazizadeh Hamideh; Moohebati Mohsen; Ebrahimi Mahmoud; Heidari Bakavoli Alireza; Azarpajouh Mahmoud Reza; Ferns Gordon A; Mogharebzadeh Vahid; Ghayour Mobarhan Majid^*

来源：Biofactors, 2018, 44(3): 263-271.

DOI：10.1002/biof.1424

• pro-oxidant
• antioxidant
• PAB
• metabolic syndrome
• hs-CRP
• uric acid

There is persuasive evidence that oxidative stress and inflammation are features of the metabolic syndrome (MetS). We have investigated the relationship between serum pro-oxidant-antioxidant balance (PAB), serum uric acid, and high sensitive C-reactive protein (hs-CRP) in 7,208 participants from the MASHAD study cohort, who were categorized as having MetS, or not, using International Diabetes Foundation (IDF) criteria. Serum hs-CRP was measured by Polyethylene glycol (PEG)-enhanced immunoturbidimetry method using an Alycon analyzer (ABBOTT, Chicago, IL, USA). A colorimetric method was used to determine serum PAB. Serum PAB values were significantly higher in the individuals with MetS compared to those without (P<0.001). Furthermore, there was a step-wise increase in mean serum PAB concentrations as the number of components of the MetS increased. The combination of features of MetS had different association with serum PAB and hs-CRP. Multiple linear regression analysis showed that body mass index (BMI, B=2.04, P<0.001), physical activity level (PAL, B=18.728, P=0.001), serum uric acid (B=-1.545, P=0.003), and serum C-reactive protein (B=0.663, P<0.001) were associated with serum PAB in individuals with MetS. Multiple logistic regression analysis showed that serum PAB (B=0.002, P<0.001, CI=1.001-1.003), serum C-reactive protein (B=0.007, P< 0.015, CI=1.001-1.013), and serum uric acid (B=0.207, P<0.001, CI=1.186-1.277) were all significantly associated with MetS. Serum PAB was strongly associated with serum uric acid and serum hs-CRP. Moreover, serum PAB as well as serum uric acid and serum hs-CRP were independently associated with MetS. Individual features of MetS were also associated with serum hs-CRP and PAB.

• 出版日期2018-6