Adipokine Zinc-alpha 2-Glycoprotein Regulated by Growth Hormone and Linked to Insulin Sensitivity

作者：Balaz Miroslav; Ukropcova Barbara; Kurdiova Timea; Gajdosechova Lucia; Vlcek Miroslav; Janakova Zuzana; Fedeles Jozef; Pura Mikulas; Gasperikova Daniela; Smith Steven R; Tkacova Ruzena; Klimes Iwar; Payer Juraj; Wolfrum Christian; Ukropec Jozef^*

来源：Obesity, 2015, 23(2): 322-328.

DOI：10.1002/oby.20856

ObjectiveHypertrophic obesity is associated with impaired insulin sensitivity and lipid-mobilizing activity of zinc-2-glycoprotein. Adipose tissue (AT) of growth hormone (GH) -deficient patients is characterized by extreme adipocyte hypertrophy due to defects in AT lipid metabolism. It was hypothesized that zinc-2-glycoprotein is regulated by GH and mediates some of its beneficial effects in AT.
MethodsAT from patients with GH deficiency and individuals with obesity-related GH deficit was obtained before and after 5-year and 24-month GH supplementation therapy. GH action was tested in primary human adipocytes. Relationships of GH and zinc-2-glycoprotein with adipocyte size and insulin sensitivity were evaluated in nondiabetic patients with noncancerous cachexia and hypertrophic obesity.
ResultsAT in GH-deficient adults displayed a substantial reduction of zinc-2-glycoprotein. GH therapy normalized AT zinc-2-glycoprotein. Obesity-related relative GH deficit was associated with almost 80% reduction of zinc-2-glycoprotein mRNA in AT. GH increased zinc-2-glycoprotein mRNA in both AT of obese men and primary human adipocytes. Interdependence of GH and zinc-2-glycoprotein in regulating AT morphology and metabolic phenotype was evident from their relationship with adipocyte size and AT-specific and whole-body insulin sensitivity.
ConclusionsThe results demonstrate that GH is involved in regulation of AT zinc-2-glycoprotein; however, the molecular mechanism linking GH and zinc-2-glycoprotein in AT is yet unknown.

• 出版日期2015-2