Autologous renal cell cancer vaccines using heat shock protein-peptide complexes

作者：Aalamian Maryam; Fuchs Ephraim; Gupta Renu; Levey Daniel L^*

来源：Urologic Oncology-Seminars and Original Investigations, 2006, 24(5): 425-433.

DOI：10.1016/j.urolonc.2005.08.009

• heat shock protein
• autologous
• renal cell carcinoma

Investigations into the role of heat shock proteins (HSPs) in immune response have progressed well into a third decade, and indications of their use for the treatment of renal cell carcinoma (RCC) in the adjuvant setting will be revealed in the near future when a randomized phase III clinical trial is completed. Additional ongoing and planned randomized clinical trials will test the efficacy of HSP-based vaccines in more advanced stages of RCC. This review describes the compelling scientific rationale behind testing HSPs in RCC against the backdrop of other immunotherapeutic approaches in this indication.

• 出版日期2006-10