Antiviral activity of mixed-valence rare earth borotungstate heteropoly blues against influenza virus in mice

作者：Liu, J^*; Mei, WJ; Li, YG; Wang, E; Ji, LN; Tao, PZ

来源：Antiviral Chemistry and Chemotherapy, 2000, 11(6): 367-372.

DOI：10.1177/095632020001100603

• rare earth borotungstate heteropoly blues
• influenza virus
• toxicity
• antiviral activity

The acute and accumulated toxicity of the rare earth borotungstate heteropoly blues, HPB-2, Ce2H3[(BW9W2Mn)-W-VI-Mn-V(H2O)O-39]. 12H(2)O, which is active against influenza virus in Kunming mice, were investigated in Kunming mice following oral and intraperitoneal administration. The activity of HPB-2 against influenza virus (FM1) in the mice was then investigated. HPB-2, given either orally (p.o.) or intraperitoneally (i.p.), was shown to have activity. HPB-2 was shown to be more effective than the positive control, ribavirin, and it was also found that i.p. administration was more effective than p.o. administration.

• 出版日期2000-11
• 单位中山大学; 东北师范大学; 中国医学科学院医药生物技术研究所