Mass spectrometry-based monitoring of millisecond protein-ligand binding dynamics using an automated microfluidic platform

作者:Cong Yongzheng; Katipamula Shanta; Trader Cameron D; Orton Daniel J; Geng Tao; Baker Erin S; Kelly Ryan T
来源:Lab on a Chip, 2016, 16(9): 1544-1548.
DOI:10.1039/c6lc00183a

摘要

We present a novel microfluidic platform that features rapid mixing of protein and ligand solutions, variable incubation times, and an integrated electrospray ionization source for mass spectrometry-based monitoring of protein–ligand binding dynamics.

  • 出版日期2016
  • 单位Pacific Northwest National Laboratory