Does thyroid-stimulating hormone influence the prognosis of patients with endometrial cancer? A multicentre trial

作者：Seebacher V; Hofstetter G; Polterauer S; Reinthaller A; Grimm C; Schwameis R; Taucher S; Wagener A; Marth C; Concin N^*

来源：British Journal of Cancer, 2013, 109(1): 215-218.

DOI：10.1038/bjc.2013.282

• thyroid-stimulating hormone
• hypothyroidism
• endometrial cancer
• prognosis
• survival
• thyroid gland

Background: Thyroid function has been suggested to interfere with tumour biology and prognosis in different cancers. The present study was performed to investigate the impact of pre-therapeutic serum thyroid-stimulating hormone (TSH) levels on the prognosis of patients with endometrial cancer. %26lt;br%26gt;Methods: Pre-therapeutic serum TSH was investigated in 199 patients with endometrial cancer. After stratification in TSH risk groups, univariate and multivariable survival analyses were performed. %26lt;br%26gt;Results: Elevated TSH was independently associated with poor disease-specific survival in univariate/multivariable survival analyses (P=0.01 and P=0.03, respectively). %26lt;br%26gt;Conclusion: Thyroid-stimulating hormone may serve as a novel and independent prognostic parameter for disease-specific survival in patients with endometrial cancer.

• 出版日期2013-7-9