Anti-inflammatory effect of oleuropein on microglia through regulation of Drp1-dependent mitochondrial fission

作者：Park Junghyung; Min Ju Sik; Chae Abcl Unbin; Lee Joon Yeop; Song Kyung Sik; Lee Hyun Shik; Lee Hong Jun; Lee Sang Rae; Lee Dong Seok^*

来源：Journal of Neuroimmunology, 2017, 306: 46-52.

DOI：10.1016/j.jneuroim.2017.02.019

• Oleuropein
• Microglia
• Inflammation
• Mitochondrial dynamics
• Drp1
• ROS

Oleuropein is a primary phenolic compound found in olive leaf and Fraxinus rhynchophylla. Here, we investigated the impact of oleuropein on LPS-induced BV-2 microglial cells. Oleuropein suppressed the LPS-induced increase in pro-inflammatory mediators, such as nitric oxide, and pro-inflammatory cytokines, via inhibition of ERK/p38/NF-kappa B activation and reactive oxygen species (ROS) generation. Furthermore, it suppressed LPS-induced excessive mitochondrial fission, which regulates mitochondrial ROS generation and pro-inflammatory response by diminishing Drp1 dephosphorylation. Collectively, we demonstrated that oleuropein suppresses pro inflammatory response of microglia by inhibiting Drp1-dependent mitochondrial fission. Our findings suggest a potential role of oleuropein in microglial inflammation-mediated neurodegenerative disorders.

• 出版日期2017-5-15