Microwave-Assisted Synthesis of Some 1H-1,2,4-Triazol-3-one Derivatives

作者：Karaali Nesrin; Mentese Emre^*; Yilmaz Fatih; Usta Asu; Kahveci Bahittin

来源：South African Journal of Chemistry, 2013, 66: 72-76.

• Triazole
• oxadiazole
• hydrazine hydrate
• microwave irradiation

4-Amino-5-(methyl/ethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one were synthesized from the reaction of (methyl/ethyl)-ester ethoxycarbonyl hydrazone with hydrazine hydrate and then, converted to corresponding Schiff bases using 9H-fluorene-3-carbaldehyde. Ester, hydrazide and oxadiazole derivatives were synthesized starting from Schiff bases in three steps. All reactions occurred under conventional conditions and microwave irradiation. The obtained results were compared.

• 出版日期2013