A novel glutathione peroxidase mimic with antioxidant activity

作者：Ren XJ; Yang LQ; Liu JQ; Su D; You DL; Liu CP; Zhang K; Luo GM^*; Mu Y; Yan GL; Shen JC

来源：Archives of Biochemistry and Biophysics, 2001, 387(2): 250-256.

DOI：10.1006/abbi.2000.2238

• glutathione peroxidase
• beta-cyclodextrin
• artificial enzyme
• antioxidant
• selenium

Many diseases are associated with the overproduction of hydroperoxides that inflict cell damage. A novel cyclodextrin derivative, 6A,6B-diseleninic acid-6A '; ,6B '; -selenium bridged beta -cyclodextrin (6-diSeCD), was synthesized to be a functional mimic of glutathione peroxidase (GPX) that normally removes these hydroperoxides. The mimic had high catalytic GPX activity of 13.5 U/mu mol, which is 13.6-fold higher than ebselen (PZ51), and was chemically and biologically stable in vitro. Antioxidant activity was studied by ferrous sulfate/ascorbate-induced mitochondria damage model system. These data show that the mimic has great antioxidant activity. Such mimics may result in better clinical therapies for diseases mediated by hydroperoxides.

• 出版日期2001-3-15
• 单位吉林大学