LOW DOSE BOLUS PANTOPRAZOLE FOR ACUTE PEPTIC ULCER BLEEDING IS EFFECTIVE

作者：Ucbilek Enver^*; Altintas Orhan Sezgin Engin

来源：Acta Medica Mediterranea, 2015, 31(1): 91-96.

• peptic ulcer bleeding
• low dose
• pantoprazole

Introduction: Proton pump inhibitors are the most effective treatment for peptic ulcer bleeding. However, the PPI dose needed to prevent re-bleeding are not well established. We aimed to compare high-dose infusion of pantoprazole and low-dose bolus pantoprazole in patients given endoscopic treatment for control of peptic ulcer bleeding.
Materials and methods: Patients admitted with peptic ulcer bleeding in which the bleeding was controlled by endoscopic intervention were randomized to high-dose and low dose groups. The primary endpoints were early re-bleeding, need for blood transfusion, surgery, mortality, and duration of hospitalization. Cost of treatment was also determined.
Results: Re-bleeding occurred in 10 patients (27.8%) in the high-dose group and in 3 patients (8.1%) in the low-dose group (p = 0.028). Surgery, mortality, and duration of hospitalization were similar in the two groups. The pantoprazole cost per patient was 252.62 Turkish Liras (TL) in the high-dose group and 104.02 TL in the low-dose group.
Conclusion: High-dose and low-dose pantoprazole treatment after endoscopic treatment had similar efficacy in the control of peptic ulcer bleeding in our study population. The low-dose treatment had lower costs and was easier to administer. Thus, low-dose bolus pantoprazole administration following successful endoscopic therapy should be considered for treatment of peptic ulcers.

• 出版日期2015