Design of a Numbering-up System of Monolithic Microreactors and Its Application to Synthesis of a Key Intermediate of Valsartan

作者：Nagaki Aiichiro^*; Hirose Katsuyuki; Tonomura Osamu; Taniguchi Satoshi; Taga Toshiki; Hasebe Shinji; Ishizuka Norio; Yoshida Jun ichi^*

来源：Organic Process Research & Development, 2016, 20(3): 687-691.

DOI：10.1021/acs.oprd.5b00414

Synthesis of a key intermediate of valsartan was accomplished using five parallel monolithic micro reactors connected to a split-and-recombine-type flow distributor. The channel resistances of the flow distributor were designed so as to minimize the flow maldistribution among reactors by using pressure drop compartment model, which is analogous to electrical resistance network

• 出版日期2016-3