A general method for detecting protease activity via gelation and its application to artificial clotting

作者:Bremmer Steven C; Chen Jing; McNeil Anne J*; Soellner Matthew B
来源:Chemical communications, 2012, 48(44): 5482-5484.
DOI:10.1039/c2cc31537h

摘要

A modular system for detecting protease activity via enzyme-triggered gel formation is described. Protease-specific recognition sequences are utilized to achieve enzyme specificity. Artificial blood clotting is demonstrated by activating endogenous thrombin to trigger gelation in fibrinogen-deficient blood plasma.

  • 出版日期2012