Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease

作者：Marques Payao Spencer Luiz; Goncalves Gisela Moraes; de Labio Roger William; Horiguchi Lie; Mizumoto Igor; Rasmussen Lucas Trevizani; de Souza Pinhel Marcela Augusta; Silva Souza Doroteia Rossi; Bechara Marcelo Dib; Chen Elizabeth; Mazzotti Diego Robles; Ferreira Bertolucci Paulo Henrique; Cardoso Smith Marilia de Arruda

来源：Journal of Neuroimmunology, 2012, 247(1-2): 59-62.

DOI：10.1016/j.jneuroim.2012.03.012

• Alzheimer's disease
• Interleukin-1 beta
• Polymorphisms
• Haplotypes
• Receptor antagonist

Our study aimed to associate IL-1 beta and IL-1RN polyrnorphisms with AD disease in comparison with elderly control group from Sao Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1 beta) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protective effect for AD when compared to EC (p=0.005), whereas -511C/-31C/1-repetition VNTR haplotype was associated as a risk factor for AD (p=0.021). Taken together, we may suggest that there is a relevant role of IL-1 genes cluster in AD pathogenesis in this Brazilian population.

• 出版日期2012-6-15