Dye diffusion from microcapsules with different shell thickness into mammalian skin

作者：Yow Huai Nyin; Wu Xiao; Routh Alexander F^*; Guy Richard H

来源：European Journal of Pharmaceutics and Biopharmaceutics, 2009, 72(1): 62-68.

DOI：10.1016/j.ejpb.2008.11.004

• Encapsulation
• Skin diffusion
• Microcapsules

Oil-in-water microcapsules with varying shell thicknesses were fabricated via a coacervation technique, whereby evaporation of volatile solvents induced the shell-forming polymer to precipitate, phase separate and migrate to the oil/water interface to form microcapsules. These microcapsules encapsulated a lipophilic dye within their cores and were applied topically onto porcine skin for 6 h. Results indicated that the dye preferentially accumulated within the skin furrows and hair follicles, though the dye did not penetrate beyond the stratum corneum. A model estimates the diffusion coefficients of dye through the microcapsule shell and within the skin to be approximately 10(-18) and 10(-16) m(2) s(-1), respectively.

• 出版日期2009-5