Antioxidant and Amine Oxidase Inhibitory Activities of Hydroxyurea

作者：Liu Yuh Hwa; Wu Wen Chun; Lu Yeh Lin; Lai Ying Jang^*; Hou Wen Chi

来源：Bioscience Biotechnology and Biochemistry, 2010, 74(6): 1256-1260.

DOI：10.1271/bbb.100096

• antioxidant activity
• hydroxyurea (HU)
• monoamine oxidase (MAO)
• semicarbazide-sensitive amine oxidase (SSAO)

Hydroxyurea (HU, NH2CONHOH), or hydroxycarbamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicarbazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 mu M.

• 出版日期2010-6