Assessment of anti-prothrombin antibodies in thrombosis complicating inflammatory bowel diseases

作者：Saibeni Simone^*; Etchevers Maria J; Tassies Dolors; Panes Julian; Reverter Joan C; Danese Silvio; Pique Josep M; Bruno Savino; Vecchi Maurizio; Ga**arrini Antonio; Sans Miquel

来源：International Journal of Colorectal Disease, Clinical and Molecular Gastroenterology and Surgery, 2013, 28(9): 1281-1286.

DOI：10.1007/s00384-013-1696-7

• Crohn%26apos
• s disease
• Ulcerative colitis
• Thrombosis
• Antibodies
• Prothrombin

Purpose In inflammatory bowel diseases (IBD), risk of thrombosis and production of antibodies are increased. In autoimmune and inflammatory disorders, a role of anti-prothrombin (aPT) antibodies in developing thrombosis has been hypothesised. The aim of the study is to evaluate the prevalence of aPT antibodies in IBD patients, with and without thrombosis. %26lt;br%26gt;Methods Thirty-three IBD patients with thrombosis, 33 IBD patients without thrombosis matched for sex, age, diagnosis and disease activity and 66 sex-and age-matched healthy controls were enrolled. Thrombosis was considered recent when blood sample was obtained within 3 months from the event. %26lt;br%26gt;Results Prevalence of aPT antibodies in thrombotic IBD patients (3/33, 9.1%), non-thrombotic IBD patients (4/33, 12.1%) and in healthy subjects (3/66, 4.5 %) did not result significantly different (p=0.377). The prevalence of aPT antibodies was more frequent in ulcerative colitis (6/32, 18.7 %) than in Crohn%26apos;s disease (1/34, 2.9 %) and healthy controls (p=0.022). Among thrombotic IBD patients, the prevalence of aPT antibodies was higher in those with recent (2/9, 22.2 %) than in those with previous thrombosis (1/24, 4.2 %) (p=0.103). All thrombotic IBD patients with aPT antibodies were affected by ulcerative colitis with previous history of deep venous thrombosis. %26lt;br%26gt;Conclusions aPT antibodies do not appear to play a relevant role in thrombosis complicating IBD course. A possible association in ulcerative colitis patients with DVT could not be excluded.

• 出版日期2013-9