Automated Liquid-Liquid Extraction by Pneumatic Recirculation on a Centrifugal Microfluidic Platform

作者：Kazarine Alexei; Kong Matthew C R; Templeton Erin J; Salin Eric D^*

来源：Analytical Chemistry, 2012, 84(16): 6939-6943.

DOI：10.1021/ac301421k

In this technical note, a liquid-liquid extraction technique was performed using pneumatic liquid recirculation on a centrifugal microfluidic device. Non-contact pneumatic pumping enabled a multi-cycle liquid-liquid extraction process using aqueous iodine in a potassium iodide solution and hexadecane while requiring a minimal amount of space on the device. The extraction process was completely automated on the device following sample introduction and required only 50 s for each extraction cycle. The pumping rate achieved during liquid recirculation was 120 +/- 10 mu L/min. A recycling process such as the one demonstrated would be difficult to implement in a conventional centrifugal microfluidic system.

• 出版日期2012-8-21