Acute Liver Failure Induced by Carthamus tinctorius Oil: Case Reports and Literature Review

作者：de Ataide E C^*; Reges Perales S; de Oliveira Peres M A; Bastos Eloy da Costa L; Quarella F; Valerini F G; Chueiri Neto F; Silveira Bello Stucchi R; de Fatima Santana Ferreira Boin I

来源：Transplantation Proceedings, 2018, 50(2): 476-477.

DOI：10.1016/j.transproceed.2018.01.010

Background. Acute liver failure (ALF) is a clinical syndrome that results from the abrupt loss of liver function in a patient without previous liver disease. The most frequent causes are viral hepatitis, drug induced, and autoimmune disease, but in 20% of cases no cause is identified. Carthamus tinctorius (safflower) oil is used as a dietary supplement for weight loss and antioxidant. There are 4 cases described in the literature of ALF induced by the use of this substance. The objective of this study was to report 3 cases of ALF treated at the Clinical Hospital of the State University of Campinas that suggest the use of C tinctorius oil as a probable etiologic factor.
Case Reports. The 3 patients had a diagnosis of ALF according to the King's College criteria. All had a history of ingestion of this oil for weight loss. During etiologic evaluation, viral hepatitis, autoimmune diseases, or any other drug cause were excluded, thus pointing to C tinctorius oil as the triggering factor. All 3 patients underwent liver transplantation: 2 had good postoperative evolution, and 1 died 12 days after the procedure.
Conclusions. Two cases are described in which the hepatic insufficiency induced by C tinctorius oil was successfully treated through liver transplantation. This highlights the risk of misuse of this substance for weight loss.

• 出版日期2018-3