Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

作者：Debets Marjoke F; van Berkel Sander S; Schoffelen Sanne; Rutjes Floris P J T; van Hest Jan C M^*; van Delft Floris L

来源：Chemical communications, 2010, 46(1): 97-99.

DOI：10.1039/b917797c

A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.

• 出版日期2010