Non-peptide antigens activating human V gamma 9/V delta 2 T lymphocytes

作者：Poupot M; Fournie JJ^*

来源：Immunology Letters, 2004, 95(2): 129-138.

DOI：10.1016/j.imlet.2004.06.013

• non-peptide antigens
• V gamma 9/V delta 2 T lymphocytes
• gamma delta T cell

Various non-peptidic ligands which specifically activate most of circulating human Vgamma9Ndelta2 T lymphocytes are now known. Most of these are so-called phosphoantigens and directly trigger the Vgamma9Ndelta2 TCR expressing cells, without need for MHC-restricted presentation molecules. Although some potent phosphoantigens currently involved in clinical trials are chemically- synthesized molecules, most of the natural antigens were isolated from microbial cultures. The structures and biosynthesis of phosphoantigens are reviewed here and the possible physiological significance of their recognition by gammadelta T lymphocytes is discussed.

• 出版日期2004-9