Association of anti-Ro/SSA antibody with response to biologics in patients with rheumatoid arthritis

作者：Hagiwara Shinya; Tsuboi Hiroto; Honda Fumika; Takahashi Hidenori; Kurata Izumi; Ohyama Ayako; Yagishita Mizuki; Abe Saori; Kurashima Yuko; Kaneko Syunta; Kawaguchi Hoshimi; Takahashi Hiroyuki; Ebe Hiroshi; Yokosawa Masahiro; Asashima Hiromitsu; Hirota Tomoya; Umeda Naoto; Kondo Yuya; Matsumoto Isao; Sumida Takayuki^*

来源：Modern Rheumatology, 2016, 26(6): 857-862.

DOI：10.3109/14397595.2016.1153567

• Anti-Ro/SSA antibody
• Abatacept (ABT)rheumatoid arthritis
• Infliximab (IFX)
• Tocilizumab (TCZ)

Objective: To compare the effectiveness of three different biologics in anti-Ro/SSA antibody-positive and antibody-negative patients with rheumatoid arthritis (RA).
Methods: The study subjects were 110 biologics naive patients with RA who started treatment with biologics and examined for anti-Ro/SSA antibody between December 2003 and March 2014. For patients treated with intravenous infliximab (IFX), tocilizumab (TCZ), or abatacept (ABT), we compared the clinical characteristics and changes in composite disease activity index, such as DAS28, SDAI, and CDAI, for 12 months in anti-Ro/SSA antibody-positive and antibody-negative patients.
Results: We examined 59 patients (nine were positive and 50 were negative for anti-Ro/SSA antibody) treated with IFX, 27 patients (5 positive and 22 negative) treated with TCZ, and 24 patients (13 positive and 11 negative) treated with ABT. For patients treated with IFX, parameters of disease activity did not change significantly from baseline in anti-Ro/SSA antibody-positive patients, whereas they improved in antibody-negative patients. On the other hand, treatment with TCZ and ABT significantly decreased disease activity, relative to baseline, in both anti-Ro/SSA antibody-positive and antibody-negative patients. Anti-Ro/SSA antibody-positive patients treated with IFX showed higher frequency of HACA and seroconversion of ANA, and lower serum TGF-beta levels.
Conclusions: Positivity to anti-Ro/SSA in RA seems to confer resistance to IFX via production of HACA and ANA, and low serum TGF-beta levels, but not to TCZ and ABT.

• 出版日期2016