Amyopathic dermatomyositis developing rapidly progressive interstitial lung disease with elevation of anti-CADM-140/MDA5 autoantibodies

作者：Sato Shinji^*; Kuwana Masataka; Fujita Takashi; Suzuki Yasuo

来源：Modern Rheumatology, 2012, 22(4): 625-629.

DOI：10.1007/s10165-011-0558-9

• Anti-CADM-140 autoantibodies
• Anti-MDA5 autoantibodies
• Clinically amyopathic dermatomyositis (CADM)
• Dermatomyositis (DM)
• Rapidly progressive interstitial lung disease (RP-ILD)

Anti-clinically amyopathic dermatomyositis (CADM)-140/MDA5 autoantibodies are specifically detected in patients with dermatomyositis and are known to have a strong association with rapidly progressive interstitial lung disease (RP-ILD). Here we report an amyopathic dermatomyositis (ADM) patient who developed RP-ILD characterized by elevated anti-CADM-140/MDA5 titer. Respiratory symptoms gradually improved, and anti-CADM-140/MDA5 titer decreased in parallel to below the cutoff level. It may be useful to quantify CADM-140-specific autoantibodies for monitoring disease activity in patients with ADM and RP-ILD.

• 出版日期2012-8