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摘要
The reactions of fuoroalkylated acetylides with various nitrones were investigated. When nitrones with an alkyl substituent were employed, hydroxylamines were obtained in high yields, and smooth dehydroxylation followed, to give the corresponding propargylamines. Nitrones with an aryl substituent underwent nucleophilic addition and subsequent intratnolecular cyclization, affording the corresponding fluoroalkylated dihydroisoxazoles in moderate yields. These sequences were also extended to chiral versions.
- 出版日期2009-4-1
