An H-phosphonate strategy for the synthesis of 2 ',3 '-dideoxynucleoside triphosphates and homodinucleotides

作者：Sun, Qi^*; Liu, Si; Sun, Jian; Gong, Shan-Shan

来源：Chinese Chemical Letters, 2014, 25(3): 427-430.

DOI：10.1016/j.cclet.2013.11.029

• 2 ',3 '-Dideoxynucleosides
• Nucleoside triphosphate
• Homodinucleotide
• H-Phosphonate

The triphosphates and homodinucleotides of AZT and d4T have been efficiently synthesized from the corresponding nucleoside S'-H-phosphonate monoesters via the reactive pyridinium phosphoramidate intermediates.

• 出版日期2014-3
• 单位江西科技师范大学