Antioxidant and cytotoxic flavonoids from the flowers of Melastoma malabathricum L.

作者：Susanti Deny^*; Sirat Hasnah M; Ahmad Farediah; Ali Rasadah Mat; Aimi Norio; Kitajima Mariko

来源：Food Chemistry, 2007, 103(3): 710-716.

DOI：10.1016/j.foodchem.2006.09.011

• Melastoma malabathricum
• Melastomataceae
• flavonoids
• antioxidant
• cytotoxic

Phytochemical and bioactivity studies of the flowers of Melastoma malabathricum L. (Melastomataceae) have been carried out. The ethyl acetate extract yielded three compounds, identified as naringenin, kaempferol and kaempferol-3-O-D-glucoside, and methanol extract gave kaempferol-3-O-(2", 6"-di-O-p-trans-coumaroyl) gluco side and kaempferol-3-O-D-glucoside. The crude extracts and isolated compounds were screened for their antioxidant and cytotoxic activities. The antioxidant assay was carried out by the DPPH radical-scavenging electron spin resonance (ESR) spectroscopic method. The cytotoxicity was measured by the MTT assay against a MCF7 cell line. Naringenin, kaempferol, kaempferol-3-O-D-glucoside, kaempferol-3-O-(2",6"-di-O-p-trans-coumaroyl) glucoside, ethyl acetate and methanol extracts were found to be active as radical-scavengers with IC50 values of 0.52 mM, 81.5 mu M, 1.07 mM, 35.8 mu M, 7.21 mu g/ ml and 6.59 mu g/ml, respectively. Naringenin and kaempferol-3-O-(2",6"-di-O-p-trans-coumaroyl)glucoside were also found to be active in inhibiting cell proliferation of MCF7 with IC50 values of 0.28 mu M and 1.3 mu M, respectively.

• 出版日期2007