Association of eNOS and ACE gene polymorphisms and plasma nitric oxide with risk of non-small cell lung cancer in South India

作者：Peddireddy Vidyullatha; Badabagni Siva Prasad; Gundimeda Sandhya Devi; Mundluru Hema Prasad

来源：Clinical Respiratory Journal, 2018, 12(1): 207-217.

DOI：10.1111/crj.12517

<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p>The role of <jats:italic>ACE</jats:italic> and <jats:italic>eNOS</jats:italic> gene polymorphisms and their association with various cancers were reported. However, their role in the lung cancer is unclear.</jats:p></jats:sec><jats:sec><jats:title>Objectives</jats:title><jats:p>In this study, we analyzed <jats:italic>eNOS</jats:italic> and <jats:italic>ACE</jats:italic> gene polymorphisms and the risk of non‐small cell lung cancer (NSCLC) in South Indian population.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>For the <jats:italic>eNOS</jats:italic> gene, the homozygous “AA” genotypic frequency was significantly associated with NSCLC with an overall risk of 3.6‐fold (<jats:italic>P</jats:italic> = 0.006, odds ratio = 3.58, 95% confidence interval = 1.66, 7.723). The heterozygous “I/D” genotypic frequency of <jats:italic>ACE</jats:italic> gene was significantly higher in NSCLC patients when compared to the controls with a 2.29‐fold risk for NSCLC. Multiple regression analyses indicated that gender, smoking status, and polymorphisms in <jats:italic>eNOS</jats:italic> and <jats:italic>ACE</jats:italic> genes as the strongest predicting factors for an increased susceptibility to NSCLC.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>We report for the first time that polymorphisms in the <jats:italic>eNOS</jats:italic> “A/A” (homozygous mutant) and ACE “I/D” genotypes might contribute to the increased risk of NSCLC in the South Indian population.</jats:p></jats:sec>

• 出版日期2018-1