Amyloid-beta plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

作者：He, Zhuohao; Guo, Jing L.; McBride, Jennifer D.; Narasimhan, Sneha; Kim, Hyesung; Changolkar, Lakshmi; Zhang, Bin; Gathagan, Ronald J.; Yue, Cuiyong; Dengler, Christopher; Stieber, Anna; Nitla, Magdalena; Coulter, Douglas A.; Abel, Ted; Brunden, Kurt R.; Trojanowski, John Q.; Lee, Virginia M-Y^*

来源：Nature Medicine, 2018, 24(1): 29-+.

DOI：10.1038/nm.4443

• A-BETA
• NEUROFIBRILLARY TANGLES
• TRANSGENIC MICE
• MOUSE MODEL
• DISEASE
• DEPOSITION
• TAUOPATHY
• APP
• AGE
• TRANSMISSION

Alzheimer's disease (AD) is characterized by extracellular amyloid-beta (A beta) plaques and intracellular tau inclusions. However, the exact mechanistic link between these two AD lesions remains enigmatic. Through injection of human AD-brain-derived pathological tau (AD-tau) into A beta plaque-bearing mouse models that do not overexpress tau, we recapitulated the formation of three major types of AD-relevant tau pathologies: tau aggregates in dystrophic neurites surrounding A beta plaques (NP tau), AD-like neurofibrillary tangles (NFTs) and neuropil threads (NTs). These distinct tau pathologies have different temporal onsets and functional consequences on neural activity and behavior. Notably, we found that A beta plaques created a unique environment that facilitated the rapid amplification of proteopathic AD-tau seeds into large tau aggregates, initially appearing as NP tau, which was followed by the formation and spread of NFTs and NTs, likely through secondary seeding events. Our study provides insights into a new multistep mechanism underlying A beta plaque-associated tau pathogenesis.

• 出版日期2018-1