A facile one-pot synthesis of chiral beta-amino esters

作者：Bunlaksananusorn T^*; Rampf F

来源：Synlett, 2005, (17): 2682-2684.

DOI：10.1055/s-2005-917108

• reductive amination
• beta-amino esters
• beta-keto esters
• Ru-ClMeOBIPHEP catalyst

We report a facile one-pot synthesis of chiral beta-amino esters via direct reductive amination of beta-keto esters with ammonium acetate (NH4OAc) and H-2 in the presence of chiral Ru-CIMeOBIPHEP catalysts using 2,2,2-trifluoroethanol (TFE) as a solvent, leading to beta-amino esters in high yields with high enantioselectivities (up to 99% ee).

• 出版日期2005-10-17