Application of L-prolinamides as highly efficient organocatalysts for the asymmetric Michael addition of unmodified aldehydes to nitroalkenes

作者：Naziroglu Hayriye Nevin; Durmaz Mustafa; Bozkurt Selahattin; Demir Ayhan Sitki; Sirit Abdulkadir^*

来源：Tetrahedron: Asymmetry , 2012, 23(2): 164-169.

DOI：10.1016/j.tetasy.2012.01.008

The asymmetric Michael addition of aldehydes to nitroolefins was investigated using a combination of L-prolinamide derivatives and various acidic additives. (S)-1,1%26apos;-Bi-2-naphthol was found to be the most effective co-catalyst and afforded the nitroaldehyde products with excellent yields (up to 95%), enantiomeric excesses (up to 99%) and diastereoselectivity ratios (up to 99:1).

• 出版日期2012-1-31