Advantages of histamine H4 receptor antagonist usage with H1 receptor antagonist for the treatment of murine allergic contact dermatitis

作者：Matsushita Ayuko; Seike Masahiro^*; Okawa Haruka; Kadawaki Yayoi; Ohtsu Hiroshi

来源：Experimental Dermatology, 2012, 21(9): 714-715.

DOI：10.1111/j.1600-0625.2012.01559.x

• high-fat diet
• inflammation
• Irs1-knockout
• lithium
• ulcerative dermatitis

Ulcerative dermatitis (UD) is a severe inflammatory skin disorder with an unknown aetiology. Recently, insulin receptor substrate 1 KO mice were shown to be fully resistant to UD. In this study, we showed that high-fat diet (HFD) feeding significantly increased incidence of UD in wild type (WT) C57BL/6 mice, as did lithium-mediated inhibition of GSK3-beta, which is a key negative regulator of IRS1. In contrast to WT mice, resistance to UD was fully preserved in HFD-fed Irs1-KO mice. Our results identify IRS1 as a key determinant of UD pathogenesis and establish a direct link between diet composition, obesity-induced inflammation and chronic ulceration.

• 出版日期2012-9