Dimethyl Acetylenedicarboxylate: A Versatile Tool in Organic Synthesis

作者:Neochoritis Constantinos G; Zarganes Tzitzikas Tryfon; Stephanidou Stephanatou Julia*
来源:Synthesis (Germany), 2014, 46(5): 537-585.
DOI:10.1055/s-0033-1340615

摘要

This review presents the recent progress in the chemistry of dimethyl acetylenedicarboxylate (DMAD). The interest in and applications of this powerful reagent with more than 135 years of history have greatly increased in the last 10 years, further proving its versatility. Undoubtedly, DMAD can be a multi-tool in the quest of molecular complexity and diversity. The extreme structural diversity of the products described in this review illustrates the powerful potential of DMAD as a building block in organic synthesis.

  • 出版日期2014-3