Genetic and Vascular Modifiers of Age-Sensitive Cognitive Skills: Effects of COMT, BDNF, ApoE, and Hypertension

作者：Raz Naftali^*; Rodrigue Karen M; Kennedy Kristen M; Land Susan

来源：Neuropsychology, 2009, 23(1): 105-116.

DOI：10.1037/a0013487

• aging
• vascular risk
• memory
• fluid intelligence
• single nucleotide polymorphisms

Several single nucleotide polymorphisms have been linked to neural and cognitive variation in healthy adults. We examined contribution of three polymorphisms frequently associated with individual differences in cognition (Catechol-O-Methyl-Transferase, Va1158Met, Brain-Derived-Neurotrophic-Factor Va166Met, and Apolipoprotein E epsilon 4) and a vascular risk factor (hypertension) in a sample of 199 volunteers (age 18-82). Genotypes were determined from buccal culture samples, and cognitive performance was assessed in 4 age-sensitive domains-fluid intelligence, executive inhibition), associative memory, and processing speed. We found that Younger age and COMT Met/Met genotype, associated with low COMT activity and higher prefrontal dopamine content, were independently linked to better performance in most of the tested domains. Homozygotes for Val allele of BDNF polymorphism exhibited better associative memory and faster speed of processing than the Met allele carriers, with greater effect for women and persons with hypertension, Carriers of ApoE epsilon 4 allele evidenced steeper age-related increase in costs of Stroop color interference, but showed no negative effects on memory. The findings indicate that age-related cognitive performance is differentially affected by distinct genetic factors and their interactions with vascular health status.

• 出版日期2009-1