MRI abnormalities following febrile status epilepticus in children The FEBSTAT study

作者：Shinnar Shlomo^*; Bello Jacqueline A; Chan Stephen; Hesdorffer Dale C; Lewis Darrell V; MacFall James; Pellock John M; Nordli Douglas R Jr; Frank L Matthew; Moshe Solomon L; Gomes William; Shinnar Ruth C; Sun Shumei

来源：Neurology, 2012, 79(9): 871-877.

DOI：10.1212/WNL.0b013e318266fcc5

Objective: The FEBSTAT study is a prospective study that seeks to determine the acute and long-term consequences of febrile status epilepticus (FSE) in childhood. %26lt;br%26gt;Methods: From 2003 to 2010, 199 children age 1 month to 5 years presenting with FSE (%26gt;30 minutes) were enrolled in FEBSTAT within 72 hours of the FSE episode. Of these, 191 had imaging with emphasis on the hippocampus. All MRIs were reviewed by 2 neuroradiologists blinded to clinical details. A group of 96 children with first simple FS who were imaged using a similar protocol served as controls. %26lt;br%26gt;Results: A total of 22 (11.5%) children had definitely abnormal (n = 17) or equivocal (n = 5) increased T2 signal in the hippocampus following FSE compared with none in the control group (p %26lt; 0.0001). Developmental abnormalities of the hippocampus were more common in the FSE group (n = 20, 10.5%) than in controls (n = 2, 2.1%) (p = 0.0097) with hippocampal malrotation being the most common (15 cases and 2 controls). Extrahippocampal imaging abnormalities were present in 15.7% of the FSE group and 15.6% of the controls. However, extrahippocampal imaging abnormalities of the temporal lobe were more common in the FSE group (7.9%) than in controls (1.0%) (p = 0.015). %26lt;br%26gt;Conclusions: This prospective study demonstrates that children with FSE are at risk for acute hippocampal injury and that a substantial number also have abnormalities in hippocampal development. Follow-up studies are in progress to determine the long-term outcomes in these children. Neurology (R) 2012;79:871-877

• 出版日期2012-8