Assessing Cardiovascular Disease Risk among Young Women with a History of Delivering a Low-Birth-Weight Infant

作者：Dietz Patricia M^*; Kuklina Elena V; Bateman Brian T; Callaghan William M

来源：American Journal of Perinatology, 2013, 30(4): 267-273.

DOI：10.1055/s-0032-1323589

• low birth weight
• fetal growth
• cardiovascular disease
• preterm

Objective To assess the prevalence and risk factors of cardiovascular disease (CVD) among younger women by pregnancy history.
Methods Cross-sectional study using 1999 to 2006 National Health and Nutrition Examination Survey including women aged 20 to 64 years who had delivered at least one infant (n = 4820). Women self-reported pregnancy history and a clinician diagnosed CVD; CVD risk factors included hypertension (mean systolic blood pressure [BP] >= 140 mm Hg or mean diastolic BP >= 90 mm Hg, or currently treated), high cholesterol (total cholesterol >= 240 mg/dL or currently treated), diabetes (self-report or hemoglobin A1c >= 6.5), and smoking (self-report or cotinine-verified). Multivariable logistic regression was used to assess the association between pregnancy history and CVD.
Results Of the women we studied, 4.6% had CVD; 3.1% had delivered a term low-birth-weight infant (TLBWI). Women with a history of TLBWI had an adjusted odds ratio (AOR) of 2.07 (95% confidence intervals [CI] 1.08 to 3.99) for CVD compared with women without a history of LBWI. Adjustment for hypertension and high cholesterol mildly attenuated the association (AOR 1.85, 95% CI 0.89 to 3.83). Among women without CVD (n = 4555), 23.11 with a history of TLBWI had two risk factors compared with 14.0% of those without a history of LBWI (p = 0.0016).
Conclusion Women with a history of TLBWI should be informed of a possible increased risk of CVD and encouraged to receive screenings as recommended.

• 出版日期2013-4