Direct Copper(I)-Catalyzed Cycloaddition of Organic Azides with TMS-Protected Alkynes

作者：Cuevas Felix; Oliva Ana I; Pericas Miquel A^*

来源：Synlett, 2010, (12): 1873-1877.

DOI：10.1055/s-0030-1258120

• alkynes
• azides
• cycloaddition
• tandem reaction
• click chemistry

A methodology for the direct use of trimethylsilyl-protected alkynes in the copper(I)-mediated alkyne-azide cycloaddition reaction without the need of a previous deprotection step is reported. This methodology is selective for the trimethylsilyl in front of other silicon-based C(sp)-H protecting groups.