Ambiguous nucleus regulates the proliferation and percentage of T lymphocytes in peripheral blood

作者：Wang, Wei; Chen, Wei; Mei, Yingwu; Guo, Bin; Yang, Zhanqing; Fu, Shoupeng; Yue, Zhanpeng; Liu, Juxiong^*

来源：Neural Regeneration Research, 2011, 6(35): 2761-2767.

DOI：10.3969/j.issn.1673-5374.2011.35.007

• ambiguous nucleus
• electrical stimulation
• T lymphocytes
• proliferation
• neuroimmune regulation
• parasympathetic nervous system

The aim of this study was to examine the immunomodulatory role of the unilateral ambiguous nucleus (Amb). We performed electrical stimulation of the unilateral Amb, electrical stimulation of the left parietal cortex and the lateral hypothalamus following unilateral Amb lesion, as well as microinjection of acetylcholine chloride and hemicholine-3 into the unilateral Amb, and electrical stimulation of the unilateral Amb after injection of atropine, mecamylamine, propranolol, and phentolamine. Results showed that the number and proliferation of peripheral blood T lymphocytes were increased after electrical stimulation of the unilateral Amb. The cholinergic neurons in the Amb released choline substances to alter cellular immunity, thus confirming that the Amb mediates the neuro-immunomodulatory process.

• 出版日期2011-12
• 单位吉林大学