Multifarious immunotherapeutic approaches to cure HIV-1 infection

作者：Imami Nesrina^*; Herasimtschuk Anna A

来源：Human Vaccines & Immunotherapeutics, 2015, 11(9): 2287-2293.

DOI：10.1080/21645515.2015.1021523

• antiretroviral therapy
• functional cure
• HIV-1
• immunotherapy
• retroviral persistence
• T-cell responses
• therapeutic vaccines

Immunotherapy in the context of treated HIV-1 infection aims to improve immune responses to achieve better control of the virus. To date, multifaceted immunotherapeutic approaches have been shown to reduce immune activation and increase CD4 T-lymphocyte counts, further to the effects of antiretroviral therapy alone, in addition to improving HIV-1-specific T-cell responses. While sterilizing cure of HIV-1 would involve elimination of all replication-competent virus, a functional cure in which the host has long-lasting control of viral replication may be more feasible. In this commentary, we discuss novel strategies aimed at targeting the latent viral reservoir with cure of HIV-1 infection being the ultimate goal, an achievement that would have considerable impact on worldwide HIV-1 infection.

• 出版日期2015-9-2